Wine consumption and risk of cognitive decline in adults: A systematic review of human studies, 2013–2025
DOI:
https://doi.org/10.14295/bjs.v6i2.953Keywords:
wine, cognitive function, dementia, moderate drinking, polyphenolsAbstract
Wine consumption has been proposed to influence cognitive health because of its polyphenolic compounds, but evidence regarding its effects remains inconsistent. This systematic review evaluated the association between wine consumption and cognitive outcomes in adults. We conducted a systematic review following PRISMA 2020 guidelines and registered the protocol with PROSPERO (CRD420261303152). PubMed/MEDLINE, Scopus, Web of Science, PsycINFO, and the Cochrane Library were searched for studies published between Jan 1, 2013, and Dec 31, 2025. Eligible studies included randomized controlled trials and observational studies involving adults aged 18 years or older that examined wine consumption and cognitive outcomes. Two reviewers independently screened studies, extracted data, and assessed methodological quality. Findings were synthesised narratively because of methodological heterogeneity. Of 3,120 records identified, 30 studies met the inclusion criteria (24 observational studies and six intervention studies) involving more than 100,000 participants. Most observational studies reported that low-to-moderate wine consumption was associated with better cognitive performance, slower cognitive decline, or lower dementia risk compared with abstinence or heavy drinking. A meta-analysis included within the review reported a 28% lower risk of cognitive decline among wine consumers than non-consumers (RR 0·72, 95% CI 0·63–0·80). However, several studies found that these associations were attenuated after adjustment for socioeconomic and lifestyle factors. Evidence from intervention studies was limited and inconsistent, whereas heavy alcohol consumption was consistently associated with adverse cognitive outcomes. The evidence base is dominated by studies from high-income and non-African settings, limiting its applicability to African populations. Low-to-moderate wine consumption is frequently associated with favourable cognitive outcomes in observational studies; however, current evidence remains insufficient to establish a causal neuroprotective effect. Heavy alcohol consumption is consistently associated with cognitive harm. Future research should prioritise longitudinal African cohorts with repeated alcohol-exposure assessment, culturally appropriate cognitive measures, and rigorous control for socioeconomic confounding.
References
Abbas, J. R., Chu, M. M. H., Jeyarajah, C., Isba, R., Payton, A., McGrath, B., Tolley, N., & Bruce, I. (2023). Virtual reality in simulation-based emergency skills training: A systematic review with a narrative synthesis. Resuscitation Plus, 16(1), 100484. https://doi.org/10.1016/j.resplu.2023.100484
Akagi, Y., Kabayama, M., Gondo, Y., Masui, Y., Yasumoto, S., Klinpudtan, N., Srithumsuk, W., Ikebe, K., Yamamoto, K., Rakugi, H., & Kamide, K. (2022). Alcohol drinking patterns have a positive association with cognitive function among older people: a cross-sectional study. BMC Geriatrics, 22(1). https://doi.org/10.1186/s12877-022-02852-8
Armas Rojas, N. B., Lacey, B., Simadibrata, D. M., Ross, S., Varona-Pérez, P., Burret, J. A., & González, M. D., Emberson, J., Peto, R., & Lewington, S. (2021). Alcohol consumption and cause-specific mortality in Cuba: prospective study of 120 623 adults. EClinicalMedicine Part of THE LANCET Discovery Science, 33, 100692.
Boccardi, V., Tagliafico, L., Persia, A., Page, E., Ottaviani, S., Borgarelli, C., Pisciotta, L., Mecocci, P., & Monacelli, F. (2024). The potential effects of red wine and its components on neurocognitive disorders: A narrative review. Nutrients, 16(20), 3431. https://doi.org/10.3390/nu16203431
Crocker, T. F., Lam, N., Jordão, M., Brundle, C., Prescott, M., Forster, A., Ensor, J., Gladman, J., & Clegg, A. (2023). Risk-of-bias assessment using Cochrane’s revised tool for randomized trials (RoB 2) was useful but challenging and resource-intensive: observations from a systematic review. Journal of Clinical Epidemiology, 161, 39-45. https://doi.org/10.1016/j.jclinepi.2023.06.015
Farzaei, M. H., Rahimi, R., Nikfar, S., & Abdollahi, M. (2018). Effect of resveratrol on cognitive and memory performance and mood: A meta-analysis of 225 patients. Pharmacological Research, 128, 338-344. https://doi.org/10.1016/j.phrs.2017.08.009
Gillespie, K. M., Kemps, E., White, M. J., & Bartlett, S. E. (2025). Moderate alcohol consumption does not protect cognitive function when controlling for income and cultural factors. Frontiers in Aging Neuroscience, 17, 1569069. https://doi.org/10.3389/fnagi.2025.1569069
Grønkjær, M. S., Flensborg-Madsen, T., Osler, M., Sørensen, H. J., Becker, U., & Mortensen, E. L. (2024). Differences in associations of three types of alcoholic beverages with age-related cognitive decline in men. Nutrients, 16(21), 3714. https://doi.org/10.3390/nu16213714
Jeon, K. H., Han, K., & Jeong, S-M. (2023). Changes in alcohol consumption and risk of dementia in a nationwide Cohort in South Korea. JAMA Network Open, 6(2), e2254771. https://doi.org/10.1001/jamanetworkopen.2022.54771
Koch, M., Fitzpatrick, A. L., Rapp, S. R., Nahin, R. L., Williamson, J. D., Lopez, O. L., DeKosky, S. T., Kuller, L. H., Jensen, M. K., & Sink, K. M. (2019). Alcohol consumption and risk of dementia and cognitive decline among older adults with or without mild cognitive impairment. JAMA Network Open, 2(9), e1910319. https://doi.org/10.1001/jamanetworkopen.2019.10319.
Langås, J. (2025). Lifestyle factors across the life course and age at menopause-population-based studies of women in Norway. Accessed on: February 05, 2026. Available at: https://core.ac.uk/download/pdf/656003489.pdf
Lobo, E., De la Cámara, C., Gracia-García, P., Saz, P., López-Antón, R., & Lobo, A. (2025). Cognitive trajectories in older adults and associated mortality and predictors. Social Psychiatry and Psychiatric Epidemiology, 60(12), 2887-2895. https://doi.org/10.1007/s00127-025-02862-y
Lucerón-Lucas-Torres, M., Cavero-Redondo, I., Martínez-Vizcaíno, V., Saz-Lara, A., Pascual-Morena, C., & Álvarez-Bueno, C. (2022). Association between wine consumption and cognitive decline in older people: A Systematic review and meta-analysis of longitudinal studies. Frontiers in Nutrition, 9, 863059. https://doi.org/10.3389/fnut.2022.863059
Luchini, C., Stubbs, B., Solmi, M., & Veronese, N. (2017). Assessing the quality of studies in meta-analyses: Advantages and limitations of the Newcastle Ottawa Scale. WJMA – World Journal of Meta-Analysis, 5(4), 80-84. http://dx.doi.org/10.13105/wjma.v5.i4.80
Martínez-Lapiscina, E. H., Clavero, P., Toledo, E., Estruch, R., Salas-Salvadó, J., Julián, B. S., Sanchez-Tainta, A., Ros, E., Valls-Pedret, C., & Martinez-Gonzalez, M. Á. (2013). Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial. Journal of Neurology, Neurosurgery & Psychiatry, 84(12), 1318-1325. https://doi.org/10.1136/jnnp-2012-304792
Minister, P., & Paetongtarn, P. (2023). Aim digest february 2025-news from around the world. Available at: https://alcoholinmoderation.com/wp-content/uploads/2025/02/february_2025.pdf. Accessed on: February 05, 2026.
Minozzi, S., Cinquini, M., Gianola, S., Gonzalez-Lorenzo, M., & Banzi, R. (2020). The revised Cochrane risk of bias tool for randomized trials (RoB 2) showed low interrater reliability and challenges in its application. Journal of Clinical Epidemiology, 126, 37-44. https://doi.org/10.1016/j.jclinepi.2020.06.015
Morgan, R. L., Whaley, P., Thayer, K. A., & Schünemann, H. J. (2018). Identifying the PECO: A framework for formulating good questions to explore the association of environmental and other exposures with health outcomes. Environmental International, 121(10), 1027-1031. https://doi.org/10.1016/j.envint.2018.07.015
Neafsey, E., & Collins, M. A. (2011). Moderate alcohol consumption and cognitive risk. Neuropsychiatric Disease and Treatment, 7(1), 465-484.
Nooyens, A. C. J., Bueno-De-Mesquita, H. B., Van Gelder, B. M., Van Boxtel, M. P. J., & Verschuren, W. M. M. (2014). Consumption of alcoholic beverages and cognitive decline at middle age: the Doetinchem Cohort Study. British Journal of Nutrition, 111(4), 715-723. https://doi.org/10.1017/S0007114513002845
Paul, M., & Leeflang, M. M. (2021). Reporting of systematic reviews and meta-analysis of observational studies. Clinical Microbiology and Infection, 27(3), 311-314. https://doi.org/10.1016/j.cmi.2020.11.006
Rees, A. (2023). Editor, Aim digest october 2024-news from around the world. International Digest on alcohol and health and the responsible consumption of alcohol. https://doi.org/10.1093/postmj/qgae039
Stockwell, T., Zhao, J., Clay, J., Levesque, C., & Sanger, N. (2024). Why do only some cohort studies find health benefits from low-volume alcohol use? A systematic review and meta-analysis of study characteristics that may bias mortality risk estimates. Journal of Studies on Alcohol and Drugs, 85(4), 441-452. https://doi.org/10.15288/jsad.23-00283
Topiwala, A. (2017). Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline: longitudinal cohort study. The BMJ, 357(16), 1190-1192, 2017. https://doi.org/10.1136/bmj.j2353
Xie, Z., Zhang, Z., Bi, K., Huang, S., Zhao, M., & Du, J. (2025). Moderate drinking benefits cognitive health in middle-aged and older Chinese: A latent class growth model analysis based on CHARLS. Journal of Affective Disorders, 380, 439-448. https://doi.org/10.1016/j.jad.2025.03.134
Zaw, J. J. T., Howe, P. R. C., & Wong, R. H. X. (2017). Does phytoestrogen supplementation improve cognition in humans? A systematic review. Annals of the New York Academy of Sciences, 1403(1), 150-163. https://doi.org/10.1111/nyas.13459
Zhang, R., Shen, L., Miles, T., Shen, Y., Cordero, J., Qi, Y., Liang, L., & Li, C.(2020). Association of low to moderate alcohol drinking with cognitive functions from middle to older age among US adults. JAMA Network Open, 3(6), e207922-e207922. https://doi.org/10.1001/jamanetworkopen.2020.7922
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