Metal-free, acid-base, and organocatalyst-promoted semi-green protocols for the efficient construction of structurally diverse & highly functionalized pyrimidine derivatives: A long-term review (1876–2026)
DOI:
https://doi.org/10.14295/bjs.v5i8.898Keywords:
pyrimidine synthesis, metal-free, organocatalysis, semi-green protocols, acid-base promotionAbstract
This review summarizes the 150-year development of pyrimidine synthesis from 1876 to 2026, highlighting progress in metal-free, acid–base-mediated, and organocatalytic methodologies for the construction of structurally diverse, highly functionalized pyrimidine derivatives. Emphasis is placed on the synthetic efficiency, practical applicability, and sustainability of these approaches, including classical condensation reactions and modern semi-green methodologies. This review aims to serve as a comprehensive reference for the development of efficient, sustainable, and metal-free strategies for the synthesis of complex pyrimidine scaffolds.
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Copyright (c) 2026 Mohammad Mizanur Rahman, Abul Faiz Golam Masud Reza, Mohammad Lokman Hossain, Abul Kalam Mohammad Lutfor Rahman, Rabiul Islam
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