First report, phytochemical screening, and antioxidant and acetylcholinesterase inhibition activities of Macrolepiota mastoidea (Fr.) Singer mushroom extract in the Southwest region of Brazil
DOI:
https://doi.org/10.14295/bjs.v3i12.706Keywords:
alkaloids, flavonoids, Macrolepiota genus, DPPH, acetylcholinesterase, edible mushroomsAbstract
The Agaricales family is rich in species of edible macrofungi. Macrolepiota mastoidea is a representative of this group, found in various regions of the world, including Brazil. It is an edible species with several recorded biological activities. This study aimed to report the first findings on M. mastoidea and its phytochemical screening, as well as its antioxidant activity and acetylcholinesterase inhibition in a 70% (v/v) hydroethanolic extract from fresh mushrooms. M. mastoidea was collected from a Cerrado area in the Southwest of Goiás, Brazil. The hydroethanolic extract was produced, and the phytochemical screening was conducted for various phytochemical groups. Antioxidant activity was assessed using the DPPH free radical model, and acetylcholinesterase inhibition activity was determined using Electrophorus electricus type VI. The results showed the presence of various phytochemical groups such as alkaloids, sugars, flavonoids, and tannins. The DPPH reduction activity was IC50 305.16 µg mL-1, and acetylcholinesterase inhibition was 72%. Macrolepiota mastoidea demonstrated potential for further pharmacological studies with promising biological activities.
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Copyright (c) 2024 Hugner Vicente da Silva, Marcelo Augusto Martins de Freitas, Tullyo Henrique Lima Machado, Antonio Carlos Pereira de Menezes Filho, Matheus Vinícius Abadia Ventura, Elizabete Nunes da Rocha
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