Biological activity of a benzene sulfonamide on perfusion pressure and coronary resistance using an isolated rat heart model

Authors

  • Magdalena Alvarez-Ramirez Faculty of Nutrition, University Veracruzana, Médicos y Odontologos s/n C.P. 91010, Unidad del Bosque Xalapa Veracruz, México https://orcid.org/0000-0003-0046-4342
  • Lauro Figueroa-Valverde Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche, Av. Agustín Melgar s/n, Col Buenavista C.P. 24039 Campeche, Camp., México https://orcid.org/0000-0001-6801-6402
  • Marcela Rosas-Nexticapa Faculty of Nutrition, University Veracruzana, Médicos y Odontologos s/n C.P. 91010, Unidad del Bosque Xalapa Veracruz, México https://orcid.org/0000-0001-7119-4728
  • Maria López-Ramos Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche, Av. Agustín Melgar s/n, Col Buenavista C.P. 24039 Campeche, Camp., México https://orcid.org/0000-0001-8457-0243
  • Maria Virginia Mateu-Armad Faculty of Nutrition, University Veracruzana, Médicos y Odontologos s/n C.P. 91010, Unidad del Bosque Xalapa Veracruz, México https://orcid.org/0000-0003-3283-0001
  • Eli Alejandra Garcimarrero-Espino Faculty of Nutrition, University Veracruzana, Médicos y Odontologos s/n C.P. 91010, Unidad del Bosque Xalapa Veracruz, México https://orcid.org/0000-0002-4673-7804
  • Lenin Hau-Heredia Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche, Av. Agustín Melgar s/n, Col Buenavista C.P. 24039 Campeche, Camp., México https://orcid.org/0000-0002-3174-4112
  • Regina Cauich-Carrillo University Autonomous of Quintana Roo State, Campus Chetumal, Av Erik Paolo Martinez s/nesq. Av. 4 de marzo, Col. Magisterial, C.P. 77039, México https://orcid.org/0000-0002-7166-5048
  • Julliete Mijangos-Sanchez Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche, Av. Agustín Melgar s/n, Col Buenavista C.P. 24039 Campeche, Camp., México https://orcid.org/0000-0003-1178-7112

DOI:

https://doi.org/10.14295/bjs.v3i4.540

Keywords:

benzenesulfonamide, derivatives, perfusion pressure, docking

Abstract

There are studies which indicate that some sulfonamide derivatives can produce changes in the cardiovascular system; however, their biological activity on perfusion presure and coronary resistance is not clear. The aim of this research was to evaluate the effect exerted by benzenesulfonamide, and  their derivatives (2,5-dichloro- N-(4-nitro-phenyl)-benzene-sulfonamide, 2-hydrazino-carbonyl-benzenesulfonamide, 4-(2-amino-ethyl)-benze- ne-sulfonamide, and 4-[3-(4-nitro-phenyl)-ureido]-benzene- sulfonamide) on perfusion pressure and coronary reistance.  To evaluate the biological activity of benzenesulfonamide and their derivatives on perfusion pressure and coronary reistance an isolated rat heart model was used. Furthermore, theoretical interaction of 4-(2-amino-ethyl)-benzenesul- fonamide with Calcium channel surface was determined using 6jp5 protein, nifedipine, amlodipine, verapamil and BayK 8644 as theoretical tools in a DockingServer program. The Results showed that 4-(2-amino-ethyl)-ben- zenesulfonamide decreased perfusion pressure and coronary resistance compared to benzenesulfonamide, 2,5-dichloro- N-(4-nitro-phenyl)-benzene-sulfonamide, 2-hydrazinocar- bonyl-benze-nesulfonamide, 4-[3-(4-nitro-phenyl)-ureido]- benenesulfonamide and the control conditions. Besides, theoretical data suggest that 4-(2-aminoethyl)benzenesulfo- namide could interact with aminoacid residues such as Glu614 and Ala320 involved in 6jp5 protein surface. This phenomenon could result in an ligand-Calcium channel  complex  formation to produce a decrease in perfusion pressure and vascular resistance. It is noteworthy that  biological and experimental  models used in this study is an invaluable research tool for investigating questions across the spectrum of physiologic functions of cardiovascular system such as perfusion pressure and coronary resistance

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2024-03-25

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Alvarez-Ramirez, M., Figueroa-Valverde, L., Rosas-Nexticapa, M., López-Ramos, M., Mateu-Armad, M. V., Garcimarrero-Espino, E. A., Hau-Heredia, L., Cauich-Carrillo, R., & Mijangos-Sanchez, J. (2024). Biological activity of a benzene sulfonamide on perfusion pressure and coronary resistance using an isolated rat heart model. Brazilian Journal of Science, 3(4), 11–23. https://doi.org/10.14295/bjs.v3i4.540

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Vol. 3 No. 4 (2024): Brazilian Journal of Science

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Health Sciences

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Copyright (c) 2024 Magdalena Alvarez-Ramirez, Lauro Figueroa-Valverde, Marcela Rosas-Nexticapa, Maria López-Ramos, Maria Virginia Mateu-Armad, Eli Alejandra Garcimarrero-Espino, Lenin Hau-Heredia, Regina Cauich-Carrillo, Julliete Mijangos-Sanchez

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