Biochemical interaction of twenty steroid derivatives with ribosomal protein kinase 4 S6 (RSK-4) surface using a theoretical model

Authors

  • Lauro Figueroa-Valverde Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche, Av. Agustín Melgar s/n, Col Buenavista C.P. 24039 Campeche, Camp., México https://orcid.org/0000-0001-7119-4728
  • Francisco Diaz-Cedillo Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional. Prol. Carpio y Plan de Ayala s/n Col. Santo Tomas, México, D.F. C.P. 11340 https://orcid.org/0000-0003-4613-9836
  • Marcela Rosas Nexticapa Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional. Prol. Carpio y Plan de Ayala s/n Col. Santo Tomas, México, D.F. C.P. 11340 https://orcid.org/0000-0001-7119-4728
  • Magdalena Alvarez-Ramirez Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional. Prol. Carpio y Plan de Ayala s/n Col. Santo Tomas, México, D.F. C.P. 11340 https://orcid.org/0000-0003-0046-4342
  • Maria López-Ramos Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche, Av. Agustín Melgar s/n, Col Buenavista C.P. 24039 Campeche, Camp., México https://orcid.org/0000-0002-1456-0549
  • Montserrat Melgarejo-Guttierrez Facultad de Nutrición, Universidad Veracruzana, Médicos y Odontologos s/n C.P. 91010, Unidad del Bosque Xalapa Veracruz, México https://orcid.org/0000-0002-8144-6877
  • Catalina Cervantes-Ortega Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional. Prol. Carpio y Plan de Ayala s/n Col. Santo Tomas, México, D.F. C.P. 11340 https://orcid.org/0000-0002-9085-2631
  • Maria Virginia Mateu-Armad Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional. Prol. Carpio y Plan de Ayala s/n Col. Santo Tomas, México, D.F. C.P. 11340 https://orcid.org/0000-0003-3283-0001
  • Juliette Mijangos-Sanchez Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche, Av. Agustín Melgar s/n, Col Buenavista C.P. 24039 Campeche, Camp., México https://orcid.org/0009-0007-6847-3823

DOI:

https://doi.org/10.14295/bjs.v3i2.482

Keywords:

Theoretical, RSK-4, DockingServer, steroid derivatives

Abstract

Several genetic expressions have been involved in the development of cancer such as the expression of a ribosomal kinase S6 P90 (RSK-4). It is important to mention that some compounds such as LJH685, 2073047-06-8, and SL0101 can act as RSK-4 inhibitors; however, its interaction with the surface of RSK-4 is very confusing. The aim of this research was to evaluate the interaction of twenty-nine steroid derivatives (1 to 29) with of RSK-4 surface using 6rv2 protein, LJH685, 2073047-06-8 and SL0101 as theoretical tools in the Dockingserver program. The results showed differences in the aminoacid residues involved in the interaction of steroid derivatives with 6rv2 protein surface compared with LJH685, 2073047-06-8 and SL0101. Besides, the inhibition constant for steroid derivatives 1, 12, 14, 19 and 22 was lower compared to 2073047-06-8 drug. In conclusion, the steroid derivatives 1, 12, 14, 19 and 22 could be a good alternative as RSK-4 inhibitors to decrease cancer cells growth.

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2024-02-01

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Figueroa-Valverde, L., Diaz-Cedillo, F., Nexticapa, M. R., Alvarez-Ramirez, M., López-Ramos, M., Melgarejo-Guttierrez, M., Cervantes-Ortega, C., Mateu-Armad, M. V., & Mijangos-Sanchez, J. (2024). Biochemical interaction of twenty steroid derivatives with ribosomal protein kinase 4 S6 (RSK-4) surface using a theoretical model. Brazilian Journal of Science, 3(2), 66–81. https://doi.org/10.14295/bjs.v3i2.482

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Vol. 3 No. 2 (2024): Brazilian Journal of Science

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Health Sciences

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Copyright (c) 2024 Lauro Figueroa-Valverde, Francisco Diaz-Cedillo, Marcela Rosas Nexticapa, Magdalena Alvarez-Ramirez; Maria López-Ramos; Montserrat Melgarejo-Guttierrez, Catalina Cervantes-Ortega, Maria Virginia Mateu-Armad, Juliette Mijangos-Sanchez

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