Evaluation of angiogenic and embryotoxic activity of the extract of Anadenanthera peregrina (Angico-do-Cerrado)

Authors

  • Tamíris Augusto Marinho Universidade Federal de Goiás, UFG, Instituto de Patologia Tropical e Saúde Pública (IPTSP), Programa de Pós-Graduação em Biotecnologia e Biodiversidade (PGBB) e Instituto Federal de Educação, Ciência e Tecnologia de Goiás, (IFG), Núcleo de Estudos e Pesquisas em Promoção da Saúde (NUPPS)
  • Patrícia Silva Nunes Universidade Federal de Goiás, UFG, Instituto de Patologia Tropical e Saúde Pública (IPTSP) e Instituto Federal de Educação, Ciência e Tecnologia de Goiás, (IFG), Núcleo de Estudos e Pesquisas em Promoção da Saúde (NUPPS)
  • Ruy de Souza Lino Junior Universidade Federal de Goiás, UFG, Instituto de Patologia Tropical e Saúde Pública (IPTSP)
  • Paulo Roberto de Melo Reis Pontifícia Universiidade Católica de Goiás, (PUC – Goiás), Laboratório de Estudos Experimentaos e Biotecnológicos
  • Mônica Rodrigues Ferreira Machado Universidade Federal de Jataí, UFJ, Departamento de Ciências Biológicas, Laboratório de Pesquisa e Reprodução de Zebrafish (LABFISH)
  • Nelson Jorge Silva Junior Universidade Federal de Goiás, UFG, Instituto de Patologia Tropical e Saúde Pública (IPTSP), Programa de Pós-Graduação em Biotecnologia e Biodiversidade (PGBB) e Pontifícia Universiidade Católica de Goiás, (PUC – Goiás), Laboratório de Estudos Experimentaos e Biotecnológicos
  • Antonio Carlos Pereira de Menezes Filho Instituto Federal Goiano (IFGoiano), Laboratórios de Química Tecnológica e de Hidráulica e Irrigação
  • Matheus Vinicius Abadia Ventura Faculdade UniBRAS de Goiás - Unidade Rio Verde (UniBRAS)

DOI:

https://doi.org/10.14295/bjs.v1i9.165

Keywords:

Angiogenesis inducing agents, Plants, Drugs, Toxicity, Zebrafish

Abstract

The genus Anadenanthera has been reported in the literature with antioxidant, anti-inflammatory, antimicrobial effect and healing action in wound treatment. The study aimed to evaluate, in vivo, the angiogenic and embryotoxic activities of A. peregrina extract. Angiogenesis in chicken embryo egg chorioallantoic membrane and zebrafish embryotoxicity was performed. A. peregrina extract at concentrations 62 mg mL-1 and 124 mg mL-1 were angiogenic. For embryotoxicity, the mortality rate increased with increasing concentration and increased dose and time dependent embryotoxicity was observed. The lethal concentration (LC50) ranged from 0.331mg mL-1 over the 24 hpf period to 0.007 mg mL-1 at 168 hpf (Δ% = -97.9), decreasing with increasing exposure. The heart rate decreased progressively and significantly with increasing concentration at all tested exposure times. In conclusion, it was evidenced that the extract of Anadenanthera peregrina has angiogenic activity. Nonetheless, embryotoxic effects were observed at high concentrations.

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Published

2022-09-01

How to Cite

Marinho, T. A., Nunes, P. S., Lino Junior, R. de S., Reis, P. R. de M., Machado, M. R. F., Silva Junior, N. J., Menezes Filho, A. C. P. de, & Ventura, M. V. A. (2022). Evaluation of angiogenic and embryotoxic activity of the extract of Anadenanthera peregrina (Angico-do-Cerrado). Brazilian Journal of Science, 1(9), 20–29. https://doi.org/10.14295/bjs.v1i9.165

Issue

Vol. 1 No. 9 (2022): Brazilian Journal of Science

Section

Agrarian and Biological Sciences

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Copyright (c) 2022 Tamíris Augusto Marinho, Patrícia Silva Nunes, Ruy de Souza Lino Junior, Paulo Roberto de Melo Reis, Mônica Rodrigues Ferreira Machado, Nelson Jorge Silva Jr, Antonio Carlos Pereira de Menezes Filho, Matheus Vinicius Abadia Ventura

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